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Principal Scientist, Small Molecule Assay Development

About Rezo Therapeutics
Rezo is a different kind of biopharma company.  Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.  
Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs. 
Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.
Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities.  We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements.   If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us! 
The Opportunity
We are seeking a highly enthusiastic and motivated Principal Scientist to join our Discovery Biology team. This role will be responsible for the design and execution of biochemical and biophysical assays of small molecule protein targets. Becoming a member of this team is an excellent opportunity to join Rezo at an early stage and help build the Discovery Biology function and the company from the ground up.

What You’ll Do:

  • Establish and implement expression strategies and support reagent generation to enable HTP screening and biophysical characterization of multiple protein targets
  • Design and oversee diverse, robust, and reproducible biochemical and biophysical assays across all phases of discovery and development
  • Explore and evaluate new technologies related to Protein Sciences, and contribute to long-term activity planning
  • Partner with Platform, Discovery Biology, Chemistry, and other departments to drive drug discovery efforts forward
  • Manage and analyze experimental data, interpret results, and prepare necessary materials for internal and external meetings and publications
  • Contribute to and balance multiple projects/studies in parallel in a fast-paced environment
  • Manage one or more direct reports, with potential to grow your team as the company scales

About You:

  • PhD with a focus on Biochemistry, Structural Biology or related field plus 7-10 years work experience, with a minimum of 4 years in drug discovery/development OR BS in relevant field plus 15 + years work experience, with a minimum of 8 years in drug discovery/development
  • Experience working with small molecules, required
  • Demonstrated ability to set scientific strategy and lead team to drug discovery milestones
  • Extensive protein biochemistry track record working with challenging proteins and multi-protein complexes
  • Experience characterizing protein-protein interactions and protein-small molecule binding (e.g. BLI, SPR, TR-FRET, GCI)
  • Demonstrated excellence in combining protein structure and chemistry to create new approaches to drug difficult targets
  • Background of balancing CRO and internal resources to solve problems and drive progress
  • Strong communication, organization, and interpersonal skills
  • Excellent mentoring skills, with prior management experience strongly preferred
Compensation at Rezo
The expected starting salary range for this position based in San Francisco, California is $154,000 – $215,000.  Actual starting salary will be determined based on multiple job-related factors including a candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity.  This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.  This position is also eligible for the benefits detailed below.
Benefits at Rezo
Medical (HMO or PPO), dental, and vision insurance
Discretionary time off policy
Company holidays (including summer and winter shutdown)
401(k) retirement savings program
Commuter / Mass Transit Benefit Program
Healthcare Flexible Spending Account (FSA)
Dependent care Flexible Spending Account (FSA)
Parental leave
Competitive compensation
Flexible work schedule
At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  This statement covers all facets of employment and is especially important when it comes to growing our team.  
If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!
SF Fair Chance Ordinance
Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.